Endocrine Abstracts

Introduction: Acromegaly is a chronic disorder caused by growth hormone (GH) hyperproduction which leads to significant morbidity and mortality primarily due to cardiovascular and respiratory complications. Pituitary adenoma is the main cause of GH’s hyperproduction. By current guidelines transsphenoidal surgery (TSS) is the first-line treatment in acromegaly patients.Aim: To evaluate the results of TSS in acromegaly patients 6 months after surgery....

Background: Recent studies have demonstrated antioxidant and anti-inflammatory properties of metformin and vildagliptin, that could result in some positive effects on kidney function in diabetes. Indeed, in our previous study vildagliptin attenuated routine renal dysfunction markers in insulinopenic diabetic rats, however metformin didn’t improve it. In our current study we evaluated not only glomerular dysfunction marker (albuminuria), but also novel markers of proximal ...

Background: Presently, a great deal of attention is being paid to investigation of pleiotropic effects of oral antidiabetic drugs. Several recent animal studies have suggested that vildagliptin and metformin could play some positive role in preventing the evolvement of diabetic nephropathy.Aim: This pilot study, concerned with high-fat fed heminephrectomized streptozotocin (STZ)-induced diabetic rats, aimed to evaluate and compare the effects of metformi...

Introduction: Some, but not all, previously published studies suggest that low vitamin D status maybe associated with increased risk of gestational diabetes (GDM). We examined the association of plasma plasma 25-hydroxyvitamin D (25(OH)D) concentration with GDM risk and neonatal macrosomia.Methods: 143 women were recruited before 15 weeks of gestation and were followed-up until delivery. Maternal plasma 25(OH)D concentrations were measured at 8–14 w...

Introduction: Pregnancy is characterized by a progressive insulin resistance (IR). Some, but not all, previously published studies suggest that adipokines are related to insulin resistance in pregnant women and subsequent development of gestational diabetes (GDM).The aim of this study was to investigate the relation between adiponectin, leptin, its ratio and homeostasis model assessment of IR (HOMA-IR) in the first prenatal visit and whether it could be ...

Introduction: Growth hormone (GH) level is a direct marker of active residual adenoma tissue after acromegaly surgery. However, the value of early postoperative GH for prediction of surgical cure in acromegaly has not been established and therefore is not used in everyday clinical practice.Aim: The aim of our work was to study the 24-hour basal postoperative GH level and the nadir of GH level after the oral glucose tolerance test (OGTT) two weeks after s...

Introduction: Prolactinomas are the most common pituitary adenomas. Dopamine agonists (DAs) are the treatment of choice for prolactinomas. Patients with prolactinomas normally are treated in ambulatory. In some patients there are challenges in therapy, and they need to be hospitalized.Objective: To study the clinical features and outcomes of in-patients with prolactinoma.Materials and methods: A retrospective analysis of 40 hospita...

Introduction: Persistence after transsphenoidal surgery remain a significant challenge in management of acromegaly. Value of basal growth hormone (GH) evaluation in early postoperative period as marker of acromegaly persistence has been proposed and discussed in the literature, but is not widely used in clinical practice.Aim: The goal of our study is to specify the value of basal GH level measurement 24 hours later after transsphenoidal surgery as postop...

Purpose: D631Y is a rare mutation associated with MEN2a in which there is an aspartic acid to tyrosine amino acid substitution at codon 631 in exon 11. Common clinical features of this variant of RET mutation are pheochromocytoma in 50%, medullary carcinoma in 30%, primary hyperparathyroidism is very rare. We present the patient harboring RET D631Y mutation.Clinical case: In April 2017 40-year-old woman was admitted to endocrine department of the Almazov...

BackgroundPrimary hyperparathyroidism (PHPT) is the third most common endocrine disorder mainly caused by a single parathyroid adenoma. The localization of the parathyroid adenoma is useful for increasing the recovery rate of PHPT, and reducing the complication rate. Conventional localization techniques include neck ultrasound, Tc99m-MIBI-SPECT and CT. However, each one of those has its limitations; particularly in cases of ectopic, or multiple parathyro...